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call 999 if accompanied by severe systemic illness) Signs of gallbladder disease : Right upper quadrant pain, jaundice, fever (contact GP urgently or NHS 111) Symptoms of thyroid tumours : Neck lump, hoarseness, difficulty swallowing (rare, but GLP-1 agonists carry a theoretical risk based on animal studies) [15] [21] Allergic reactions : Rash, swelling, difficulty breathing (call 999 for severe reactions with breathing difficulties) Acute kidney injury : Reduced urine output, swelling, confusion (contact GP urgently or NHS 111

It is responsible for transporting medium- and long-chain fatty acids across mitochondrial membranes, promoting their oxidation and energy production

This could allow urine to irritate and inflame the bladder

The consequences of this oxidative damage extend far beyond simple tiredness

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