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Like vitamin C, levels seem to correlate with bone density in postmenopausal women, and low levels are associated with osteoporosis

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However, the impermeability of the mitochondrial membrane to acyl-CoA molecules necessitates the shuttling of acyl-CoA through the outer mitochondrial membrane by carnitine, which is catalyzed by carnitine palmitoyl transferase 1 (CPT1) 13