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An HPLC 3D ChemStation Hewlett Packard was used for data acquisition

The increase in PKA activity also leads to closure of ATP-sensitive potassium channels, which in turn causes depolarisation of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of secretory granules and thus secretion of insulin

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GSH treatment is a promising approach, but high doses of GSH are necessary to achieve a therapeutic efficacy, due to its poor transport into the cells and tissues