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Besides, formononetin significantly inhibited angiogenesis in vivo by reducing microvessel density and phosphorylated FGFR-2 levels in tumor tissue (Wu et al., 2015)

This imbalance can have significant implications for cellular health, aging, and inflammation regulation

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Additional avenues include exploring non-canonical miRNA biogenesis pathways in rare or treatment-refractory cancers, and elucidating miRNA-mediated communication within the TME via exosomes and interactions with stromal, immune, and endothelial cells

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