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Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, et al

Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release

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Therefore, upregulating TfR1 expression increases cellular susceptibility to ferroptosis (YU et al., 2021)

The development of MS is closely related to innate immune cells, namely macrophages, microglia, and NK cells, as well as adaptive immune cells like T lymphocytes [259]