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BALB/c mice immunized with NT-CoV2-1 generated strong IgA and IgG responses in both BAL and serum, as well as strong neutralization responses against SARS-CoV-2 variants [137]

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13 However, the lack of specificity and low sensitivity of the studied biomarkers prevented further development

10.3389/fonc.2012.00102 308 MargolisK

Abbreviations ALP: alkaline phosphatase ALT: alanine aminotransferase AST: aspartate aminotransferase CKD: chronic kidney disease GGT: gamma glutamyl transpeptidase HGF: hepatocyte growth factor HPP: hypophosphatasia NSHA: nonspherocytic hemolytic anemia PLP: pyridoxal 5-phosphate TNSALP: tissue-nonspecific alkaline phosphatase Declarations Acknowledgement The support of the Herman Lopata Chair in Hepatitis Research is gratefully acknowledged