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10.1016/S0140-6736(09)60883-719692116 30 Roddy E, Doherty M

Cho CS et al

Age-related decline (Caplans findings): At birth: ~1 in 10,000 marrow cells are MSCs Teen years: ~1 in 100,000 Age 50: ~1 in 400,000 Age 80: ~1 in 2,000,000 Why perinatal sources: Epigenetic youth Day-one signaling vigor supports robust paracrine orchestration Safety and ethics Not fetal tissue