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According to the sequence and structural alignment of these identified phosphatases, an apyrase encoded by the ENTPD2 gene, that is expressed in different tissues, including colon and small intestine, may possess the ThDP phosphatase activity in mammals (140)

Supplementary Table 2 (download XLSX Metabolism focused CRISPR genetic screens in SLC25A39 -knockout Jurkat and HEK 293T cells

doi: 10.2337/diacare.28.5.1083

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It works by binding GLP-1 receptors in the pancreas, gut, and brain to increase glucose-dependent insulin secretion, slow gastric emptying, and suppress glucagon release