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J Clin Invest 107:675683 Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis

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[13] The doctrine is rooted in several assumptions: (1) prescription pharmaceutical companies have less capacity to communicate efficiently with patients, (2) the average patient generally lacks the ability to understand the pharmaceutical companys warnings and determine if the potential benefits of a particular drug outweigh the potential risks in the patients situation, and (3) physicians are in a better position to warn patients than pharmaceutical companies