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In terms of mucosal infection susceptibility, the Dectin-1 Y238X heterozygote significantly increases the risk of RVVC, and is associated with a higher Candida colonization rate in patients with hematological malignancies, requiring more frequent prophylactic antifungal treatment (Rosentul et al., 2011)

More recent peer-reviewed research has investigated AOD-9604 in chondroprotection and osteoarthritis models

however, the "LR3" modification reduces binding affinity by over 1,000-fold, significantly increasing the peptide's bioavailability and half-life in research models

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