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Future studies need to move beyond the linear explanatory framework based on a single metabolite or a single enzyme and systematically clarify, from the perspectives of temporal resolution and tissue niche resolution, the cooperative relationships between different amino acid metabolic axes and the TCA cycle, OXPHOS, and other immunometabolic modules (139)

The Pickart & Margolina 2018 review documented its extensive gene-modulating effects, and the AHK-Cu 2007 study tested a related variant on hair follicles in the lab