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As a result, high concentrations of carnosine accumulate in the muscle cells

ROS signaling regulates transcription factors, such as AP-1 and nuclear factor-kappa B (NF-B), inducing the expression of matrix metalloproteinases (MMPs) that can induce collagen oxidation and reduce the expression of types I and III collagen [26]

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However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period

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