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Notably, the Ozempic group showed an HR of 1.72 (95% CI 1.671.76), and the Wegovy group presented a significantly higher HR of 2.14 (95% CI 2.052.24)

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The first GLP-RA, twice-daily exenatide, was approved in the USA in 2005 [3] and, most recently, semaglutide received approval for administration by injection in 2017 [4] and in an oral formulation in 2019 [5]