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So, even if your regular diet would cover your nutrient demand when the appetite-surpassing effect comes into play, you start to struggle

**Enhances thermogenesis** -- you produce more body heat, which requires caloric energy Published data from the Phase 2 trial showed measurable increases in metabolic rate among retatrutide participants that were not observed in the placebo group or in comparable semaglutide/tirzepatide trials

In fact, studies of semaglutide show that about 15% of Ozempic patients develop headaches, says Akhil Shenoy, MD, endocrinologist and medical adviser at Aeroflow Diabetes

Effects of corticosteroids