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Side effects include kidney and cardiovascular disease, nerve and joint problems, vision impairments and, most importantly, diabetic ketoacidosis (DKA), a life-threatening complication

The relatively short half-life, compared with longer-acting compounds in the broader GH-axis class, is part of why Ipamorelin produces a pulsatile, physiologically patterned GH release rather than a sustained elevation, which is one of the reasons it remains a preferred reference tool for studying pulsatile GH secretion patterns