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Numbness and tingling (paresthesia) are nerve-related sensations like pins and needles or numbness

Anecdotally, some users report experiencing gastrointestinal issues like nausea, diarrhea, or constipation, as well as headache, fatigue, or irritation at the injection site

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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46

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