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As weight decreases, insulin resistance typically improves

At the same time, gross spending increased ninefold, from about $1 billion in 2019 to almost $9 billion in 2024, and gross spending per GLP-1 prescription reached $1,000 in 2024

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Availability: Commercial medications like Ozempic and Wegovy are often in high demand, leading to shortages

This careful verification approach is especially important for complex compounds like retatrutide, though the same principles apply to sourcing semaglutide from newer vendors or evaluating emerging tirzepatide sources