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How This Works Epithalon (Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG) , designed as a short analogue of the natural pineal-gland peptide epithalamin [1] [2]
32,47 The key factors increasing cell death include endoplasmic reticulum stress (leading to accumulation of unfolded and misfolded proteins within this key subcellular compartment critical in the biosynthesis of secretory and structural proteins as well as steroids, cholesterol, and other lipids), oxidative stress, mitochondrial dysfunction, inflammatory stress, and inclusions of aggregated peptides that reside within a similar intracellular milieu as do neuronal cells in PD
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