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In this regard, evidence has been provided that a mutated p53 form can sustain Nrf2-mediated antioxidant response to allow cancer cell adaptation to the tumour-typical increased ROS levels [35] and to confer chemoresistance [36]

One such antioxidant, Pycnogenol, is a standardized plant-based extract obtained from the bark of the French maritime pine and has a long historical use to treat inflammation and improve health

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doi: 10.3389/fmolb.2022.888194 108 MarinoJSIlerJDowlingARChuaSBruningJCCoppariRet al