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The drug is intended to be used in combination with a reduced-calorie diet and increased physical activity for individuals to lose weight

Both sites are clinically appropriate, but many patients find thigh injection less uncomfortable because the area has fewer nerve endings

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Luft References Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD (2009) VADT Investigators

But several clues suggest GLP-1 medications do more than shrink the number on the scale: 1) Benefits show up even when weight loss is modest