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B12 is a cofactor for succinyl-CoA synthesis and for the conversion of homocysteine to methionine

Symptoms include severe, persistent abdominal pain often radiating to the back, with nausea and vomiting

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Side effects appear to be infrequent and mild in most reported cases, and may include: Temporary injection site reactions (with subcutaneous administration) Mild headache in some individuals Vivid dreams often considered a sign of enhanced REM sleep activity Occasional mild gastrointestinal discomfort DSIP does not appear to suppress respiratory function or cause the cognitive impairment sometimes associated with sedative-hypnotic drugs