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Additionally, individuals with long-standing diabetes may already have some degree of diabetic gastroparesis, which could be worsened by GLP-1 medications

Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals

In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

J Neurol (1999) 246:11002