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Inhibition of GLP1 receptor in the brain also impedes glucose homeostasis and food intake, whereas inactivation of GLP1 receptor in the gut impairs glucosestimulated insulin secretion, reduces glucose clearance, increases levels of glucagon and increases gastric emptying after disruption of GLP1 action but not food intake or body weight after 24 h (Table 3) (Knauf et al., 2008

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