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Leptin is produced not only in the adipose tissue but also in the gastrointestinal tract, particularly in the stomach, where it has been shown to protect the gastric mucosa against various topical irritants and ulcerogens, acting, at least in part, via enhancement of mucosal blood flow due to increased production of nitric oxide (NO) caused by upregulation of NO synthase as well as the activation of brain-gut axis pathways (48, 49)

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The study supports the utility of DSIP-CBBBP in developing therapies targeting neurotransmitter dysregulation and sleep disturbances, offering a promising avenue for future research in sleep-related treatments

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Methylcobalamin accounts for most B-12 circulating in plasma