Free radicals are unstable molecules that contain unpaired electrons, which can cause damage to cells, proteins, and DNA
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Besides, protein undergoes carbonylation, another form of protein oxidative modification in which ROS groups bind to specific amino acids, affecting protein stability and activity ( Furthermore, ROS/RNS can directly attack DNA, causing oxidative DNA damage in IBD ( 2.3 Mitochondrial dysfunction Mitochondria, with their functions in energy production, calcium homeostasis, and membrane excitability, are thought to substantially impact the pathology of IBD, as their dysfunction may initiate and advance the disease
it is a dinucleotide formed from nicotinamide and adenine via a pair of ribose-phosphate linkers Summary Table Disclaimer For Research Use Only
Notably, beyond directly pathogenic metabolites like TMAO, certain gut microbes can produce molecules with dual regulatory effects through metabolic reprogramming