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Data from the Phase 2 programme (NEJM, 2023) provide an initial picture of its tolerability, which broadly mirrors that of other incretin-based therapies, with some additional considerations related to its glucagon receptor activity
This article explains the trial-based dosing rationale, escalation schedules, influencing factors, side effects, and the current regulatory status in the UK
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It should be noted that the cerebral cortex and the cerebellum interestingly lack the expression of the GLP-1R in rat models [51]
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