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Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin

*Correspondence: Hitoshi Ando, [email protected] This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Thus, unlike these studies performed in OPMDs, the studies investing the efficacy of lycopene on managing gastrointestinal precancerous lesions were predominantly limited to animal studies, observational studies, or cohort studies, RCTs evaluating on its efficacy are needed in the future

T ransient nausea, diarrhea, and mild irritation at the injection site have been reported as adverse undesirable effects in preclinical studies