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Additionally, 42.2% of patients in trial 1 and 50.2% of patients in trial 2 met the secondary endpoint of an AHI less than 5 or 5 to 14 events per hour and an Epworth Sleepiness Scale score of 10 or lesslevels at which CPAP may not be recommended

IL-1 and IL-18, two crucial pro-inflammatory cytokines synthesized during pyroptosis regulation, are implicated in the pathogenesis of inflammatory responses in renal resident cells due to their association with the expression of chemoattractant cytokines and adhesion molecules (119)

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