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The growth signal is therefore indirect and paracrine : activating those receptors releases IGF-1, IGF-2, keratinocyte growth factor and nitric oxide , and those mediators drive crypt-cell proliferation, increased villus height, deeper crypts and increased intestinal and portal blood flow [1] [5]

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TB-500, a synthetic fragment of thymosin beta-4, enhances cellular motility, reduces inflammation, and stimulates new blood vessel formation 3,4

doi: 10.1016/j.isci.2023.106190