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[33] Based on the clinical dosing regimen (2.5 to 5 mg TZP weekly), we estimated that a depot designed to release TZP continuously over four months in a rat model should contain approximately 4.5 mg of drug within a subcutaneously injectable volume (typically 0.5 to 2 mL)

Sublingual (under-the-tongue) forms dissolve in your mouth, theoretically enhancing absorption by allowing some B12 to enter the bloodstream through mucous membranes rather than relying solely on digestive uptake

Standard recommendations suggest dental cleanings every six months, but patients on GLP-1 medications experiencing dry mouth should consider cleanings every three to four months

& Coughlan, M

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