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74 In a comparative study in obese male mice of vertical sleeve gastrectomy (VSG), semaglutide treatment, and controls, both interventions improved glycemic control and reduced body weight, but VSG significantly decreased energy expenditure and induced notable bone loss, whereas semaglutide preserved BMD over six weeks

Cross-trial comparisons have real limits

While eating less helps create a calorie deficit, it can also lead to: Muscle loss Fatigue Hair thinning Nutrient deficiencies Constipation Slower metabolism That's why the goal isn't just to eat less

I tell all my patients that the list of unknowns for products used to microdose is long

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