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In vivo studies with a commonly used animal model of obesity-diabetes and enteroendocrine hyperactivity show that both GIP and GLP-1 play an important role in mediating postprandial insulin release

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Thus, the combination of semaglutide and SGLT2is offers a multifaceted approach to optimise treatment outcomes for patients with CKD and T2D, underscoring the need for further research to establish definitive guidelines for their combined use in clinical practice