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In conclusion, we provide evidence for the beneficial impact of both short- and long-acting GLP-1R agonists in human pancreatic beta cells and neurons and humanised mice, thereby providing a strong preclinical basis to clinically test these drugs in people with Wolfram syndrome

Other metal chelators do not exert any influence on mast cell function [186]

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[1] As documented in the SmPC and European Public Assessment Report (EPAR), a common cardiovascular effect observed with Wegovy is a modest increase in resting heart rate, typically by 1-4 beats per minute on average

Adequate vitamin status matters for optimal health, though supplementation beyond sufficiency rarely produces additional benefits