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We generated the Sox9-CreER mice by integrating IRES-CreERT2-SV40pA cassettes into the 3' UTR of the endogenous mouse Sox9 gene, before the aacatggaggacgattggagaatc sequence via Cas9/RNA mediated gene targeting in zygotes

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It is detected in reticulocytes but upon maturation its content decreases and it is absent in mature erythrocytes [223]

Cognitive behavioral therapy (CBT) has shown promise in treating insomnia and may help improve sleep quality, thereby reducing the likelihood of waking up with a headache