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As in mice, plasma mDNA concentrations and glutamate dehydrogenase (GDH) activity (a mitochondrial enzyme) rise, reflecting mitochondrial injury

The SURMOUNT-1 Phase 3 trial published in The New England Journal of Medicine enrolled 2,539 adults with obesity and demonstrated mean body weight reduction of 20.9% at 72 weeks on tirzepatide 15mg weekly versus 3.1% placebo

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The observations potentially support the supposition that the rise in cortical and total BMC might be due to enhanced bone growth resulting in increased bone dimensions, while the volumetric BMD remained unchanged

Secretins can be identified by highly-conserved C-terminal secretin domains that form the OM-embedded portion of the complex 21,22