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GLP-1s work by engaging the reward systems of the brain and endocrine system, effectively suppressing the dopamine reward for impulsive behavior, making those behaviors less and less appealing

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In a clinical trial, adults who switched from high-dose injectable obesity drugs to oral GLP-1 pill Foundayo were able to maintain most of their previous weight loss over 1 year, with relatively limited weight regain

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Amadi CN, Offor SJ, Frazzoli C, et al