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Common gastrointestinal effects of Wegovy include: Nausea (very common, particularly during dose escalation) Diarrhoea (very common) Vomiting, constipation, and abdominal discomfort Reduced appetite (therapeutic effect, but may feel uncomfortable initially) Antibiotics frequently cause: Diarrhoea (particularly broad-spectrum antibiotics like amoxicillin or co-amoxiclav) Nausea and abdominal cramping Disruption of normal gut flora In some cases, antibiotic-associated colitis ( Clostridioides difficile infection) When taking both medications simultaneously, gastrointestinal symptoms may be additive , meaning you might experience more pronounced nausea or diarrhoea than with either medication alone