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The sublingual route is a delivery mechanism that gets semaglutide into systemic circulation through mucous membranes, but this does not create the kind of oral fluid residue that saliva drug tests detect, and even if it did, the target antibodies in those tests would not respond to it

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Frequently Asked Questions What is the best day of the week to inject semaglutide

For injectable semaglutide, some patients report that evening administration allows them to sleep through peak nausea periods, which may occur several hours after injection