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Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

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The compound remains in Phase 3 clinical trials, with multiple studies expected to report results throughout this year

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To begin, we assessed overall germline sizes at the L4 stage, which were comparable in wild-type, fbf-1 fbf-2 and puf-3 puf-11 , but much smaller in quadruple mutants (Figure 4A-D)

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