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Hypoxia limits ROS generation and lipid peroxidation, reducing ferroptosis sensitivity

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Doskey CM, van t Erve TJ, Wagner BA, Buettner GR

In prior rodent studies, the supplementation of glycine and n-acetylcysteine (GlyNAC), which includes the glutathione precursor amino acids glycine and cysteine provided as NAC, can 1) correct GSH synthesis and concentrations, 2) lower ABBREVIATION OxS, and 3) improve mitochondrial dysfunction and insulin resistance