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The brain is highly susceptible to oxidative stress a condition in which theres an imbalance between free radical production and your bodys ability to counteract them with antioxidants

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The male brains greater dependency on retinoic acid signaling, influenced by testosterone, makes it more vulnerable to vitamin A deficiency, particularly in synaptic plasticity and hormonal regulation [17]

doi: 10.1136/annrheumdis-2021-220920 124 PeruginoCAWallaceZSZackDJQuinnSMPomaAFernandesADet al

Collectively, the gut microbiota profile of the VPA-ASD groupmarked by an elevated Firmicutes/Bacteroidota ratio and an increase in pathobionts like Desulfovibrionalesaligns with established dysbiotic features of ASD