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Discontinuation rates due to adverse events were 12.2% and 18.2% with retatrutide 9 mg and 12 mg, respectively, compared to 4.0% with placebo

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Withdrawal effects from GLP-1 medications include increased hunger, food preoccupation, and in some cases, rapid weight regain of 5-10% within the first few months off treatment

Furthermore, 65.2 percent (n=122) of patients reported treatment satisfaction and the remaining patients did not report satisfaction nor dissatisfaction with the treatment