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the small-molecule world will look to do the same, but likely as fixed-dose combinations of two or three orals rather than as single multi-functional peptides until true dual and triple small-molecule agonists can be found

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Personalized Alternatives: Genetic Testing and Optimized Monotherapy The PlexusDx Precision Peptide Genetic Test analyzes GLP1R (rs6923761), GIPR (rs1800437), FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways

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Gao et al., 2010