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It contains a DExD/H-box RNA helicase domain and a C-terminal domain (CTD) that bind dsRNA, along with two N-terminal caspase activation and recruitment domains (CARDs) that interact with the mitochondrial antiviral signaling protein (MAVS) to induce transcription of type I IFNs and downstream IFN-stimulated genes (ISGs) (99, 103)

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