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Retatrutide targets three hormone receptors, GLP-1, GIP, and glucagon, which may lead to different effects on weight loss and metabolism

When added to metformin, the GLP-1 receptor agonists achieve a mean HbA1c reduction of 0.99%,28 together with a significant weight loss (expected 2.9kg on average).40 The GLP-1 receptor agonists do not induce hypoglycemia when administered in monotherapy

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