melanotic neuroectodermal tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A Medulloblastoma Signature by DNA Methylation Profiling Melanotic Neuroectodermal Tumor of Infancy:

They need to gradually get used to higher and higher doses

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In addition, as already mentioned, in US free-living men from California, with normal Se intake at the start, a diet with high Se intake (~200 g/day for ~100 days) decreased concentration and total number of sperm, the proportion of motile sperm, and increased the proportion of tailless sperm (185)

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They are sold pre-mixed, but there are good reasons to keep them separate: their half-lives and the quantities used differ substantially, so a fixed blend forces one schedule and one ratio onto two compounds that suit different ones