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When LPS enters the bloodstream, it strongly activates the immune system, leading to the massive release of pro-inflammatory cytokines and the generation of large amounts of ROS, ultimately resulting in hepatocyte death and acute liver injury (Zhang G

Its regulation is also different from that of NRF2, which is mainly regulated by N-glycosylase 1 (NGLY1) and DNA loss inducer 1 homolog 2 (DDI2) [13, 14]

15 The transcription factor of NF-B shows a significant role in osteoarthritis pathogenesis and it stimulated by cytokine of pro-inflammatory when ECM destruction

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