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Jin-Ao Duan, [email protected] These authors have contributed equally to this work This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

3a), which allows comparison of the fitness consequences of a double knockout relative to what is expected by the simple addition of two single knockouts

In these tumors, the elimination of cancer cells with high CD38 levels is associated with an increase in helper T and cytotoxic T lymphocytes and a functional T-cell response