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This story is part of Fit at Any Age: New Frontiersa next-level guide to the latest science and tips for a stronger, longer life
Losing weight already increases the risk of gallstones, and GLP-1s seem to increase it even further
Obes Surg 2018;28:1363-71
This concern relates to a common physiological principle known as down-regulation , where the body reduces its sensitivity to a hormone when it receives a strong external signal for an extended period
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