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The GI side effects are present but manageable

A 2025 systematic review, Vasireddi et al., HSS J 2025, screened hundreds of articles and found the BPC-157 orthopaedic base to be almost exclusively animal or low-level studies, with only isolated small human reports and no rigorous randomised trials

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In parallel, we address the emerging field of chrononutrition, emphasizing that the timing of food intake and consumption of melatonin-rich or polyphenol-containing foods can enhance circadian rhythmicity, improve sleep quality, and reduce age-related metabolic and oxidative stress